Correlation of 25-Hydroxy Vitamin D and Serum Lipid Profile amongst Asymptomatic Adults in Mumbai City: A Cross-sectional Study
Published: November 1, 2022 | DOI: https://doi.org/10.7860/JCDR/2022/56822.16988
Anupa Resham Ashok Hinduja, Ashok Asthana, David Dale Chandy, Deepak Patkar, Harshad Wankhedkar
1. Clinical Associate, Department of Internal Medicine, Dr. Balabhai Nanavati, Vile Parle West, Mumbai, Maharashtra, India.
2. Director and Senior Consultant, Department of Internal Medicine, SevenHills Hospital, Mumbai, Maharashtra, India.
3. Head and Senior Consultant, Department of Endocrinology, Sir HN Reliance Hospital, Mumbai, Maharashtra, India.
4. Director and Senior Consultant, Department of Radiology, Dr. Balabhai Nanavati, Mumbai, Maharashtra, India.
5. Consultant, Department of Radiology and Imaging, Nanavati Max Superspeciality Hospital, Mumbai, Maharashtra, India.
Correspondence
Dr. Anupa Resham Ashok Hinduja,
106, Palm View, Opp. Akash Building, Sarojini Naidu Road, Mumbai, Maharashtra, India.
E-mail: hinduja.anupa@gmail.com
Introduction: Deficiency of 25-Hydroxy Vitamin D (25-OH Vitamin) is prevalent globally. Vitamin D and cholesterol metabolism are known to be linked with each other. Few International studies have attempted to relate low Vitamin D level and altered serum lipid levels. However, Indian studies are lacking, hence there is a need to conduct the studies in Indian population.
Aim: To study the correlation of the serum Vitamin D level with lipid profile amongst asymptomatic Indian adults in a tertiary care hospital, Mumbai, India.
Materials and Methods: This cross-sectional study was conducted in SevenHills Hospital, Mumbai, Maharashtra, India (tertiary care hospital), from December 2016 to August 2017. A total of 243 asymptomatic adults, visiting the wellness clinic for routine assessment of health status were randomly selected. Study participants were divided into two groups based on Vitamin D levels. Group A (n=139) with Vitamin D level <20 ng/mL, group B (n=104) with Vitamin D ≥20 ng/mL. Group B was further segregated into sub group B1 (n=60) with Vitamin D level ≥20 ng/mL to <30 ng/mL and sub group B2 (n=44) with Vitamin D level ≥30 ng/mL. Fasting blood samples were collected to measure levels of serum Vitamin D and lipid profile. The measured values of Vitamin D and serum lipids were statistically analysed for any significant relationship using Chi-square test and Unpaired t-test and Pearson’s correlation.
Results: Mean age of the participants of group A was 39.94±11.59 years and group B was 47.78±11.53 years. The difference in gender distribution and average BMI of both groups was not statistically significant (p-value=0.8599 and p-value=0.4497, respectively). On comparison of group A and group B2, average High Density Lipoprotein Cholesterol (HDL-C) level was comparatively higher amongst group B2 (52.18±11.87 mg/dL vs 45.81±12.76 mg/dL; p-value=0.0038) and average Triglyceride (TG) level was higher amongst group A (104.58±70.35 mg/dL vs 129.38±64.34 mg/dL; p-value=0.0308). There was no statistically significant linear correlation found between lipid profile parameters and Vitamin D.
Conclusion: In present study, no significant correlation between Vitamin D deficiency and serum lipid profile was found. However, a statistically significant difference was found in average levels of HDL-C and TG amongst adults with adequate Vitamin D and those with Vitamin D deficiency.
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